Abstract The excessive cytokine release and limited persistence represent major challenges for chimeric antigen receptor T (CAR-T) cell therapy in diverse tumors. Conventional CARs employ an intracellular domain (ICD) from the ζ subunit of CD3 as a signaling module. and it is largely unknown how alternative CD3 chains potentially contribute to CAR design. Here. https://parisnaturalfoodes.shop/product-category/chest-rub-stopitcold/